Evaluation of sOX-2 levels in type2 diabetic foot and nephropathic patients: association with disease activity

Background OX-2 is a member of the immunoglobulin supergene family of receptors . sOX-2 was originally described as a myeloid receptor, being expressed on macrophages, granulocytes and dendritic cells, and also expressed on T cells, Bcells, and natural killer cells. It displays a restricted tissue distribution, including activated T and B cells. sOX-2 is induced by inflammatory cytokines, including TNFand bindsto OX-2 receptor.We evaluated other biomarkers like high-sensitivity CRP(hs-CRP) in DFI patients to compare with that of healthy controls. Possible correlationswere investigated between these markers and creatinine levels, Wagner grading system (WGS), and body mass index(BMI), as well as sedimentation rate, preprandial glucose levels, and age.